Ritchie Campbell was absent for 3 episodes. (4x03), (4x04), (4x14).
Christine Hunter was absent for 3 episodes. (4x03), (4x04), (4x20).
Marly Ehrhardt was absent for absent for 1 episode. (4x14).
Lindsay was absent for 1 episode (4x14).
Barb Baran was absent for 1 episode. (4x05).
- A Decent Proposal
- How I Hate Your Mother
- White Like Me
- Snakes on a Date
- Everyone Says I Love Expect Ritchie
- Tie Me Up, Don't Tie Me Down
- So You Think You Can Date
- Self-Esteem Tempura
- Rage Against the Christine
- Guess Who's Not Coming to Dinner
- Unidentified Funk
- Happy Endings
- Notes on a 7th Grade Scandal
- What Happens in Vegas is Disgusting in Vegas
- Reckless Abandonment
- Honey, I Ran Over the Kid
- Too Close for Christine
- A Change of Heart/Pants
- He Ain't Heavy
- The Old Maid of Honor
- Love: A Cautionary Tale
- Julia Louis-Dreyfus as Christine Campbell
- Clark Gregg as Richard Campbell
- Wanda Sykes as Barbara "Barb" Baran
- Hamish Linklater as Matthew Kimble
- Trevor Gagnon as Ritchie Campbell
- Emily Rutherfurd as New Christine Hunter
- Scott Bakula as "Papa Jeff" Hunter
- Michaela Watkins as Lucy
- Alex Kapp Horner as Lindsay
- Tricia O'Kelley as Marly Ehrhardt
- Lily Goff as Ashley Ehrhardt
- Marissa Blanchard as Kelsey
- Brenda Blethyn as Angela Kimble